Here's the latest informative newsletter by Dr Ruth Ann Crystal. I've been reading these newsletters for years and always feel better knowing she's on top of things.
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Dr. Ruth Report, 5/17/26
Ruth Ann Crystal MD, May 17, 2026
Virus Summary
COVID levels are at their lowest in the last 5 years, and Influenza A and B wastewater levels are low in most parts of the country. There are still a few pockets of RSV, but RSV activity has peaked and is decreasing in most areas of the United States.
The Andes Hantavirus outbreak on the Dutch cruise ship appears to be contained.
The
WHO has labeled an outbreak of the Bundibugyo strain of Ebola in the
DRC and Uganda as a Public Health Emergency of International Concern.
(see below)
___________________________________________
Regional wastewater levels for COVID, RSV, Flu A, Flu B from Wastewater SCAN:
Research on Acute COVID infection
5/15/26
BioRxiV (MIT and others): Expansion Revealing of Pathology Resolves
Nanostructures Associated with Inflammatory Phenotypes in COVID-19
Decedent Human Brain Tissue https://buff.ly/ikYRPuI
“Expansion
revealing of pathology” (ExRPath) is a new imaging technique that
physically expands brain tissue about 20 times, allowing scientists to
see structures as small as 20 nanometers and uncover details that are
normally too crowded to detect. MIT researchers developed ExRPath, and a
faster version of this technology called 15ExMPath, which expands
tissue about 15 times in a single step instead of requiring multiple
rounds.
Using ExRPath and 15ExMPath, MIT researchers examined brain tissue from 8 people who died of COVID infection and found SARS-CoV-2 spike proteins clustered with amyloid deposits in some of the brains, a hallmark of Alzheimer’s disease
pathology. The same tissue samples also showed evidence of
neuroinflammation operating through molecular pathways associated with
Alzheimer’s disease.
Expansion revealing of pathology (ExRPath) Technique:
5/9/26 Pathogens and Immunity: Impact of Sex on Viral Shedding and Symptom Severity During Acute COVID-19 https://buff.ly/Bez0ODy
Researchers
at Brigham and Women’s Hospital tracked 668 COVID patients and found
“In the first 3 days after symptom onset, female participants exhibited
higher nasal SARS-CoV-2 RNA levels than males, but lower viral RNA
levels thereafter… Female participants also tended to have higher
symptom scores.”
Social and Advocacy
5/12/26 Bloomberg Law: Doctors Rebuffed by Courts in Long Covid and Disability Fights https://buff.ly/D7eH49L
A
Bloomberg Law analysis of 130 Long Covid disability lawsuits filed in
the United States found that judges frequently challenge the flawed
conclusions of physicians hired by disability insurers to deny claimant
benefits. The cases reveal how the private disability insurance system
creates significant obstacles for Long COVID patients.
Seniors
5/8/26
PLOS One: Life lost due to the COVID-19 pandemic: A model-based cohort
analysis of mortality displacement in the registered population of
England https://buff.ly/8LYywNe
Analysis
of 62 million registered residents of England found that a substantial
portion of older adults who died of COVID had considerable remaining
life expectancy prior to infection. Among individuals over age 65 who
died, at least 28% were projected to survive five or more additional
years had they not contracted the virus.
Pediatrics
5/11/26
BMJ Paediatrics Open: “It’s sad, and I want to go back to how things
were before”: a qualitative study of young people’s experiences of
living with long COVID https://buff.ly/2Zh0OM1
Swedish
scientists conducted qualitative interviews with 7 young people under
age 18 who are living with Long COVID. They found that “Long COVID
negatively impacted the children and young people’s lives, affecting
their relationships, education, leisure activities and sense of
identity. Dismissive and sceptical attitudes from professionals and
peers substantially increased the burden, whereas encountering
acceptance and knowledgeable professionals facilitated coping with long
COVID.”
Antiviral treatments
5/13/26 Nature: At last, a pill that can prevent COVID after exposure to infected people https://www.nature.com/articles/d41586-026-01546-0
5/13/26 NEJM: Ensitrelvir for Covid-19 Postexposure Prophylaxis in Household Contacts https://buff.ly/zWaGS6z
A clinical trial of 2,041 household contacts of COVID patients found that taking a 5 day course of the antiviral drug Ensitrelvir reduced
the rate of symptomatic COVID infection from 9% down to 3% when taken
after COVID exposure. This marks the first oral medication demonstrated
to block COVID from developing in people who have been exposed but have
not yet shown symptoms, offering particular promise for protecting
vulnerable populations.
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Long COVID
May
2026 Lancet eClinical Medicine: The next phase in Long COVID research:
addressing the ethical challenges in trials of disease-modifying
treatments https://buff.ly/DGuTUI9
A team of bioethicists, doctors, and Long COVID patients argue in a new opinion piece that researchers should not wait
for a complete mechanistic understanding of Long COVID before testing
possible treatments. The authors say that the ethical hurdles created by
Long COVID’s complexity, including the fact that it likely represents
several distinct subtypes with different underlying causes, can be
overcome with careful study design, thoughtful participant selection,
and close attention to whether the benefits of any given trial outweigh
the risks for all groups involved, including children. “Some treatment
candidates are widely used to treat diseases other than Long COVID and
are expected to be equally safe in people with Long COVID (PWLC), even
if the evidence on the given agent’s potential clinical benefits for
PWLC is still emerging (e.g., monoclonal antibodies, several immune
modulators, GLP-1 agonists).”
5/9/26 Nature: Transcutaneous auricular vagus nerve
stimulation improves dysautonomia, post-traumatic stress disorder and
cognitive impairment in long covid patients: a pilot study https://buff.ly/LiwoDBT
Researchers
at Paris Saclay conducted a pilot study of 17 Long COVID patients and
found that noninvasive electrical stimulation of the vagus nerve through
the outer ear reduced autonomic nervous system dysfunction by 56% over
eight weeks of treatment. The same intervention also produced measurable
improvements in both cognitive function and PTSD symptoms among
participants.
5/13/26 Nature: Endothelial dysfunction and metabolic biomarkers in post-COVID-19 syndrome https://buff.ly/lSTbrI3
German
scientists tracked 262 adults for nearly nine months following COVID
infection and documented persistent markers of blood vessel dysfunction
alongside measurable metabolic disruptions. Among participants reporting
severe Long COVID fatigue, elevated circulating fatty acids
associated with inflammatory processes (PUFA, LA, MUFAs, OA, PA) were a
distinguishing biochemical feature and may have potential utility as
biomarkers.
5/12/26 GeroScience: Tissue-specific autoantibody signatures reveal immune alterations undetected by routine serology in long COVID https://buff.ly/fzOXszO
Hungarian researchers compared 114 Long COVID patients to 36 pre-pandemic controls and found autoantibodies that standard ANA screening missed.
“In the majority of Long COVID patients (83% vs. 53% in controls;
p < 0.05), showing a dominant cardiovascular pattern…Vascular
autoreactivity was markedly elevated in Long COVID (34% vs. 8% in
controls; p < 0.05).” A significant portion of longitudinally studied
autoantibodies were IgM, pointing to persistent immune system disruption.
4/29/26 International Journal of Molecular Sciences: Imbalance of Excitatory and Inhibitory Neurotransmitter Systems in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome https://buff.ly/byf9y1T
A
new review from Charite in Berlin looked at “neurotransmitter systems
implicated in ME/CFS and Long COVID, focusing on potential mechanisms of
dysregulation and their roles in disease pathology and symptom
generation, as well as implications for treatment.” They found an
increase in excitatory neurotransmitters like Glutamate, Noradrenaline,
Histamine and Dopamine, and a decrease in inhibitory neurotransmitters
(GABA, Serotonin, and Glycine). This imbalance is proposed as a
mechanism underlying characteristic symptoms including post exertional
malaise, disordered sleep, chronic pain, and the paradoxical state of
simultaneous exhaustion and heightened neurological arousal (aka “tired
but wired” state).
Proposed multifactorial model:
5/12/26 Nature: Whole-protein screening and multi-modal profiling of antigen-specific CD4+ T cells at single-cell resolution https://buff.ly/HsiYmPq
Screening
for antigen-specific CD8+ T cells is well established, but profiling
CD4+ helper T cells has been too difficult to do until now. The
Institute for Systems Biology researchers monitored a single Long COVID
patient over three years and detected virus specific CD4+ helper T cells
that remained active throughout the entire observation period. The
ongoing immune response to the virus may help explain why Long COVID
symptoms can continue long after the initial infection has ended.
7/2026
(5/11/26): Brain, Behavior, & Immunity - Health: White matter
microstructural abnormalities in neurological poste-acute sequelae of
coronavirus (PASC) disease: Imaging signatures consistent with
persistent neuroinflammation https://buff.ly/lBAdVAP
Researchers
at Stony Brook University studied 80 people, including 54 with Long
COVID (PASC) and neurological symptoms such as brain fog and difficulty
concentrating, 10 unexposed controls and 19 recovered COVID controls.
They found that patients with neurological Long COVID (N-PASC) showed changes in white matter pathways involved
in memory and attention. These structural brain abnormalities were
still present approximately 2.7 years after the initial infection,
suggesting that the neurological effects of COVID infection can persist
far longer than previously thought.
Fig. 1.
Correlational tractography shows tracts with increased (red) and
decreased (blue) tractography when comparing Neuro-PASC (N-PASC) to
controls.
Share
5/9/26
Nature: One-year longitudinal cohort study of chemosensory recovery and
plasma biomarker dynamics in SARS-CoV-2 survivors https://buff.ly/4NSI77x
Hong
Kong Polytechnic University researchers tracked 120 COVID survivors
over 12 months and found that loss of smell recovered most within the
first six months, while the loss of taste improved more rapidly.
Elevated plasma alpha synuclein levels were associated with poorer recovery in the sense of smell.
5/11/26
Health and Quality of Life Outcomes: Impact of post-exertional malaise
frequency and fatigue in Long COVID patients on health-related quality
of life https://buff.ly/CGLgoFh
German
researchers studied 161 Long COVID patients and found that both the
frequency of post-exertional malaise (PEM) and the severity of fatigue
were strongly associated with reduced health-related quality of life.
Among all measured factors, experiencing post-exertional malaise (PEM) on a daily basis carried the greatest negative impact on participants’ overall health and functional capacity.
5/9/26
Nature: Interpreting hand grip strength in hospital employees with
post-COVID syndrome compared to non-infected controls: a case-control
study https://buff.ly/PthgUo1
In
a small study, German researchers tested 19 hospital employees with
Long COVID and 23 healthy controls, finding that those with post COVID
syndrome demonstrated reduced hand grip strength (HGS)
and diminished muscular recovery after repeat exertion compared to
uninfected colleagues. These objective findings indicate that persistent
fatigue commonly reported after COVID infection may have quantifiable
physical markers detectable through standardized HGS testing.
5/8/26
J of Physical Medicine & Rehabilitation (PM&R): Factors
associated with low anaerobic threshold and its impact on sleep quality
and health‐related quality of life in individuals with long COVID https://buff.ly/OcIUPSj
Researchers
in Taipei enrolled 219 Long COVID patients and found that reduced
anaerobic threshold was associated with younger age and lower exercise
capacity (peak VO2). Participants whose endurance testing revealed
impaired aerobic limits also scored significantly worse on measures of
sleep quality and quality of life.
Share
Hantavirus
5/15/26 Reuters: WHO revises hantavirus cases lower after US passenger tests negative https://buff.ly/4TCbQBQ
There have been a total of 10 confirmed Andes hantavirus
cases and 3 deaths related to the Dutch cruise ship MV Hondius. “The
Andes virus [is] a rare hantavirus strain and the only one known to be
capable of limited human-to-human transmission”. The risk to the
general public is low.
5/15/26 YLE: Something deeper than hantavirus https://buff.ly/2Bplon5
Dr.
Katelyn Jetelina from Your Local Epidemiologist discussed that public
anxiety regarding the current Andes hantavirus cruise ship outbreak
reveals something more concerning than the virus itself: a society
operating on unprocessed COVID trauma and deeply eroded trust in the CDC
and the US Government. In addition, mistrust is pervasive, and is often
fueled by social media.
Measles
CDC Measles updates (on Wed.): https://www.cdc.gov/measles/data-research/index.html
At least 95% of people need to be vaccinated against measles, in order to prevent outbreaks.
MMR vaccine coverage for kindergarteners by school year:
South Carolina Department of Public Health (Measles):
Utah Department of Public Health (Measles):
NEW: Ebola (Bundibugyo) Outbreak in DRC and Uganda
5/17/26
WHO: Epidemic of Ebola Disease caused by Bundibugyo virus in the
Democratic Republic of the Congo (DRC) and Uganda determined a public
health emergency of international concern https://buff.ly/MSHn9aX
The WHO has now designated the Bundibugyo virus Ebola outbreak in the Democratic Republic of the Congo (DRC) and Uganda a Public Health Emergency of International Concern (PHEIC),
but not a pandemic emergency. As of May 16, 246 suspected cases and 80
deaths have been reported in Ituri Province, with confirmed cases now
reaching Kampala and Kinshasa. The outbreak is likely larger than what
is being detected and reported. No approved vaccines or treatments exist
for the Bundibugyo strain of Ebola. The WHO is calling for urgent
international coordination.
UNICEF/Vincent Tremeau (2019)
U.S. Government Health News
5/13/26 Politico: White House cuts $1.3 billion in Medicaid payments to California https://buff.ly/53akP89
“The Trump administration is withholding $1.3 billion in Medicaid reimbursements to California
for failing to “combat fraud”… Though the administration has repeatedly
criticized California’s fraud oversight, this is the first time the
Centers for Medicare and Medicaid Services has targeted payments to the
state. In recent months it has withheld more than $300 million in
Medicaid reimbursements to Minnesota for suspect claims.”
Other news
5/13/26 NY Times (gift link): Why U.S. Test Scores Are in a ‘Generation-Long Decline’ https://buff.ly/DfR2IFL
Stanford researchers looked at reading and math scores
from 3rd grade through 8th grade across most U.S. school districts and
found a troubling pattern: reading scores dropped in 83% of districts
over the past decade, and math in 70% with rich districts, poor
districts, urban, rural, and every racial group being affected. Experts
point to the 2015 gutting of federal school accountability laws, the
explosion of smartphones and social media, and the COVID pandemic.
“Nearly half of American teenagers now say they are online “almost
constantly,” compared with just under a quarter who said that a decade
ago.”
Share
5/7/26 SciTech Daily: This Simple Movement Could Be Secretly Cleaning Your Brain https://buff.ly/aPi11ZB
4/27/26 Nature Neuroscience: Brain motion is driven by mechanical coupling with the abdomen https://buff.ly/GLzUdot
Penn
State researchers have found that abdominal muscle contractions during
everyday movement act like a hydraulic pump, pushing blood into the
spinal canal and gently shifting the brain within the skull. Computer
simulations indicate this motion boosts cerebrospinal fluid circulation,
potentially clearing metabolic waste.
Findings suggest routine physical activity may support brain health
through a previously unrecognized daytime mechanism that drives
interstitial fluid out of the brain, which is opposite to glymphatic flow during sleep.
5/15/26 Sutter Health and Santa Clara University to Launch the Mark & Mary Stevens School of Medicine https://buff.ly/dNgZRsx
A
new Bay Area medical school called Mark & Mary Stevens School of
Medicine is being created from a collaboration between Sutter Health and
Santa Clara University. “It is being funded in part by a $175 million
gift from Santa Clara 1984 alumna Mary (Mathews) Stevens and her
husband, venture capitalist Mark Stevens, who, along with their
children, are multi-decade Sutter Health patients.”
5/15/26 Nature: Even mild blows to the head disrupt the microbiome https://buff.ly/NpJdBYS
In
a small study, Colgate University researchers found that mild,
asymptomatic knocks to the head in American football players altered gut
bacterial composition within just 3 days. Certain bacterial species
declined in abundance as the season progressed, suggesting that repeated
mild head hits may produce cumulative shifts in the gut microbiome over
time. “Changes in bacterial populations have previously been seen after
more severe traumatic brain injuries in mice and humans, and these
variations might play a part in neurodegeneration caused by repeated
injuries.”
Photo: Rich Barnes/Colgate Athletics
Share
5/8/26 Nature Metabolism: Metformin inhibits mitochondrial complex I in intestinal epithelium to promote glycaemic control https://buff.ly/uGlkm1k
Northwestern
University scientists used transgenic mice and human metabolomic data
to show that metformin works primarily by inhibiting mitochondrial
complex I in intestinal epithelium, turning the gut into a glucose sink,
and by increasing the conversion of glucose into lactate. They note
that phenformin and berberine also block mitochondrial complex I in a
similar fashion.
5/11/26 Nature Reviews Bioengineering: Organoids as platforms for infectious disease research https://buff.ly/J8fw9do
Organoids
are miniature lab grown models of human organs that are emerging as
powerful tools for studying how infectious diseases behave in human
tissue. They mimic human biology better than animal models. A new review
in nature explains how the use of organoids may accelerate the
development of vaccines and antiviral treatments as well as strengthen
global readiness for future pandemics.
Figure 2
5/15/26 Nature Cell Biology: Mechanisms and functions of large extracellular vesicle biogenesis https://buff.ly/32arCie
A
new review published in Nature Cell Biology examines how cells produce
large extracellular vesicles (EVs), bubble shaped particles that
transport waste, signals, molecules, and even viruses between cells.
While most research has been focused on smaller EVs (<200 nm),
scientists are increasingly interested in larger EVs because of their
roles in cell communication and waste removal. Researchers also believe
these structures could become useful tools for disease diagnosis,
laboratory testing, and targeted drug delivery.
I love these names: Blebbisome and Zombosome
5/4/26 SciTech Daily: First-of-Its-Kind Discovery: Homer’s Iliad Found Embedded in a 1,600-Year-Old Egyptian Mummy https://buff.ly/32BGAae
While
excavating in Egypt, the University of Barcelona’s Oxyrhynchus
Archaeological Mission discovered a Greek papyrus fragment placed on the
abdomen of a Roman-era mummy during embalming. Analysis in early 2026
confirmed the text is from the Catalogue of Ships in Book II of Homer’s
Iliad. It is the first instance in history of a Greek literary text
deliberately incorporated into the mummification process rather than
magical or ritual content.
The papyrus, placed in the mummy’s abdomen, contains a catalogue of ships.
Credit: Professor Ignasi-Xavier Adiego.
5/14/26 Guardian: How a kindergarten teacher became the accidental guardian of 200 king penguins https://buff.ly/Lsa5c6R
Former
kindergarten teacher Cecilia Durán Gafo in Chile established the
world’s only continental king penguin reserve after poachers, selfie
seekers, and invasive mink nearly wiped out a colony that settled on her
property in 2010. Her 12-person team now protects nearly 200 penguins,
with a record 23 chicks surviving last year.
Photograph: Anastasia Austin/The Guardian
Have a good week,
Ruth Ann Crystal MD