Tuesday, June 09, 2026

Your Local Epidemiologist: The Dose, 6-9-26

Here's some vital information from Your Local Epidemiologist, Dr Katelyn Jetelina.  Make sure you read the section on major and extreme heat risk. I hope I don't have to hear about more kids dying in hot cars.

-------------------------------------

Screwworm is here, World Cup starting, things heating up (literally), and more.

Katelyn Jetelina, The Dose, 6-9-26

Movement is the name of the game this week: people, animals, insects, and the health impacts that follow.

The World Cup kicks off Thursday, pulling millions together in celebration, but where crowds gather, pathogens follow. We’re debuting a new section on the health signals worth watching. Also on the move: a parasitic, flesh-eating fly eradicated in the U.S. in 1966 has found its way back (yes, it’s as terrible as it sounds). And 48 million people are facing serious heat risk. Good news is in the mix, too.

Here’s what’s going on, and most importantly, what it means for you.


Health “weather” report

Ticks are still increasing, and all respiratory diseases are declining to very low levels.

Things are heating up

This week, 48 million people will face “major” heat risk, and 100,000 will face “extreme” heat risk.

When it comes to extreme heat, it’s not just about the temperature you see on your weather app. While 120 degrees in Phoenix isn’t great, 90 degrees in New York can be worse.

This is because the risk to your health is due to heat imbalance. That’s when your body produces more heat than it can release. Normally, sweat helps cool us down. But when it’s hot and humid, sweat doesn’t evaporate as easily. The air is already packed with moisture, making it harder for your body to cool itself and raising the risk of illness quickly.

Source: CDC Heat risk index

What this means for you: The following people should take action when their area is “orange” or higher. Everyone else, start taking action in “red.”

  • People taking medications that impair heat regulation: Certain drugs interfere with sweating, hydration, or heart function, and can even reduce your thirst sensation. Check out the list here.

  • Older adults: Aging reduces the body’s ability to sweat and regulate temperature.

  • Infants and children: Smaller bodies heat up faster, and young children may not recognize or communicate early symptoms. Kids with asthma are at high risk.

  • People with chronic diseases: Underlying conditions like heart disease strain the body’s ability to cope with heat stress.

  • Pregnant women: Pregnancy increases metabolic heat production, making it harder to stay cool. More here.

  • Outdoor workers and athletes: Prolonged physical activity in hot environments increases internal heat production.

  • People experiencing homelessness: Continuous exposure to heat, dehydration risk, and limited access to cooling or hydration increases vulnerability.

Check the HeatRisk tool to know when to avoid strenuous activity. Stay hydrated. Watch for signs and symptoms of heat stroke. Check your urine color.

Be smart with fans: Fans can help when it’s moderately hot by circulating air and helping sweat evaporate. But once temps climb above 90°F fans may actually blow more hot air onto you, increasing heat stress.

Heat exhaustion or heat stroke?

Healthy Cup: Let the games begin!

The World Cup officially kicks off Thursday! YLE is playing a key role at the national Health Security Operations Center, and each week, we’ll share what we’re seeing in the data for those heading to the games or simply curious about what happens when millions of people mix.

While we wait for the games to start, epidemiologists are watching signals at and around base camps and practice games this past week.

The risk remains low, but three signals are garnering attention for now:

  • Measles continues to spread in all three host countries, with a significant ongoing outbreak in Mexico. Seven base camps and practice games are near outbreaks, and these teams and their fans will soon disperse to other locations for the tournament. Make sure you’re up to date on the MMR vaccine and protection.

  • Norovirus (nausea, vomiting, diarrhea) is declining nationally, with one notable exception: a sharp increase in the South that’s unusual for this time of year and worth watching. This is very contagious, and hand sanitizer won’t work. Wash your hands with soap and water.

Norovirus levels in wastewater. Source: Verily
  • On heat… There was significant public concern about FIFA banning water bottles, which could become a big deal for heat-related illnesses. But on Friday, FIFA clarified (or walked back) its policy, saying attendees are allowed one 20-ounce (591 mL) unopened, soft-plastic disposable bottle (think: a bottle from a vending machine). Drink up.

We will be back next week for more.


Spotlight: Screwworm. The fly has landed.

Five cases of New World screwworm have been confirmed in the U.S. Texas declared an emergency, and Canada immediately restricted livestock imports. This bug could quickly turn into a big deal, and scientists have long warned about its return (I am surprised it didn’t come sooner, to be honest).

I called arbovirologist Dr. Miguel Arturo Saldaña in Texas to help break it down.

Screw… what?

New World screwworm (NWS) is a parasitic fly that was fully eradicated from the U.S. in 1966. It lays eggs in the open wounds of warm-blooded animals. When the eggs hatch, NWS larvae burrow into living flesh. It’s exactly as bad as it sounds, and is fatal if untreated.

Source: California Department of Food and Agriculture; annotated by Your Local Epidemiologist

How did we keep it out?

Starting in the late 1950s, scientists used the Sterile Insect Technique (SIT): mass-producing sterile males and releasing them to outcompete wild males, collapsing the fly population. It works because female flies mate only once.

Eradication moved down country by country from the U.S through Mexico and Central America over decades, eventually pushing NWS all the way to the Darién Gap in Panama (a remote landbridge of dense, mountainous rainforest). The U.S. and Panama maintained a binational barrier there, dropping roughly 20 million sterilized flies across six flights per week. For decades, it held.

But, for the past few years, it’s been crawling back up, and now, as predicted, to the U.S.

Figure from December 31, 2026 (so slightly out of date). Currently detected in the U.S. now. Source: Farm Journal

Why is it back?

A combination of factors:

  1. Cattle smuggling. NWS detections in Panama spiked from 25 cases per year to more than 6,500 in 2023, driven largely by cattle movement outside sterile fly zones.

  2. U.S. federal funding cuts. In early 2025, roughly 15,000 USDA positions were eliminated, and a USAID-funded monitoring project was terminated. Warnings passed as the pest moved north through Mexico.

  3. Loss of expertise. In many countries, veteran veterinary entomologists have retired without replacements, taking decades of specialized knowledge with them.

Why does this matter?

  • NWS spreads fast. A single female lays 200 to 300 eggs per clutch every three to seven days, up to 15 clutches in her lifetime. Eggs hatch within 24 hours; larvae feed for up to 7 days.

  • Human cases are rare and treatable when caught early. The most recent U.S. case was a traveler who returned from El Salvador last year and recovered. Pets can also be affected.

  • The bigger concern is the food system. Health and the economy are tightly linked. A 1976 Texas outbreak, a spillover from Mexico, affected 1.8 million livestock. A comparable outbreak today could cost Texas alone $1.8 billion, with losses across NWS’s historic range potentially exceeding $10.6 billion per year, and over $100 billion in broader U.S. livestock economic activity is at stake.

How do we stop it?

Same as before: SIT. Mexico is refurbishing retired rearing facilities to resume sterile fly production by summer 2026. A new U.S. facility in Texas will produce up to 300 million sterile flies per week, though experts estimate 400 to 500 million will be needed for full eradication. Ramping to capacity could take 18 months to two years. Panama is sending SIT males to the U.S. in the meantime.

What this means for you

The biggest concern is livestock, particularly cattle. Here are some tips to keep them healthy. To everyone else, the beef you eat is still safe.

Stray dogs and wildlife are also at risk; pets can be exposed too, but really only in agricultural areas. Ensure pets are on flea & tick prevention from the FDA-approved list, as products containing afoxolaner (dogs) or esafoxolaner (cats) can prevent NWS infection.

For people, risk is not uniform. Agricultural workers in the Southern states, particularly those with open wounds, sores, or skin breaks, are the most vulnerable, as flies are attracted to any open wound.

For everyone else, risk remains very low.


Good news

As always, ending on a lighter note:

  • Melinda French Gates pledged $215 million to women’s health. Specifically, expanding contraceptive access, maternal care, and menopause research globally, pushing her total investment in women’s health past $600 million over the past two years.

  • An experimental personalized skin cancer vaccine cut the risk of melanoma returning or causing death by 49% after five years when used in combination with immunotherapy. The vaccine is custom-built for each patient using genetic information from their own tumor, teaching the immune system to recognize and attack it. The vaccine still has a while to go through clinical trials, but this is welcome news given the increasing skin cancer rates.

  • Inhaled insulin approved for kids with diabetes. The FDA approved inhaled insulin (Afrezza) for children ages 6 and older with diabetes. This is the first needle-free insulin option for pediatric patients in over 100 years. It’s a mealtime insulin delivered via a small portable inhaler, replacing the multiple daily injections kids currently need at meals. Pediatric patients and parents of younger children reported greater treatment satisfaction.


Bottom line

Lots of people and animals are moving, and with them, diseases. We’re keeping an eye on it all and will keep you informed.

Love, YLE

Monday, June 08, 2026

Fixing Vincent Van Gogh

You have to take a look at this creative short video that I saw yesterday at the Althouse blog!

This Is No Time for Biden-Blinken Restraint. Let's Go!

At first I thought the fighting between Trump and Netanyahu was another ruse of the sort that was acted out right before Operation Midnight Hammer. Now I'm not too sure. 

I voted for Trump 3 times, but I'm also firmly on Israel's side here.  They don't need our permission to attack Iran after being attacked -- yet again -- by Hezbolleh.

Let's put Iran out of its misery. A "deal" we've waited weeks for can only be a bad one for Israel and for America.

---------------------------------------- 

From The Times of Israel today, 6-8-26

Trump seeks to tie Netanyahu’s hands, as the partnership that went to war 100 days ago collapses.

Telling Israel it had better not respond to an Iranian missile attack, the US president — desperate for a deal with the devilish Tehran regime — presented the PM with a stark dilemma

By David Horovitz

One hundred days after they went to war together to thwart Iran’s rogue nuclear weapons program, radically degrade its ballistic missile industry, end its support for the Hezbollah and Hamas terror armies, and create the conditions for the fall of the regime, the US-Israel alliance against the Islamic Republic on Sunday reached its nadir.

With its north battered relentlessly by Hezbollah in recent weeks, Israel resorted to a largely symbolic strike on the terror group’s Dahiyeh stronghold in Beirut, reportedly without telling the disapproving Trump administration ahead of time that it was doing so.

And, as it had warned it would, Iran responded by firing about 10 missiles at northern Israel — again sending that sector of the country rushing to bomb shelters, though causing no injuries or damage.

But as Israel prepared to “respond forcefully” against Iran, in the words of an unnamed senior Israeli official, US President Donald Trump ordered it to think again.

Before he had even spoken to Prime Minister Benjamin Netanyahu, his partner of 100 days ago, the president was telling his favorite Israeli journalist, Barak Ravid, that Israel had better not hit back: “I am going to call Bibi right now and tell him not to retaliate,” Trump vouchsafed. “Each of them had their fun. Israel had its strike and Iran had its strike. We don’t need another one.”

Trump has repeatedly denied claims that Netanyahu dragged him and the United States into the war. But he has made it increasingly clear that he is desperate to end the inadequately planned campaign, even with none of the declared US-Israeli goals achieved. He’s still insisting that he is holding out for terms that will ensure the regime never gets nuclear weapons, but there’s no guarantee of that in the leaked drafts of the memorandum of understanding he’s been working toward. And his overriding priority is to get the Strait of Hormuz reliably open again and alleviate the global energy chaos that Tehran has proved so adept at creating.

Even as Iran was firing on the north, Trump was asserting for the umpteenth time that he is days away from a deal with the manifestly obdurate and duplicitous regime: “I would say an agreement would be signed on Monday, Tuesday or Wednesday of this coming week,” the US president claimed. “And now this takes place,” he groused.

Trump’s “don’t retaliate” demand left Netanyahu with a stark choice. He could indeed surrender to the presidential diktat and hold his fire, destroying more of Israel’s deterrent capability against a gloating, triumphant Tehran, rendering Israel weak in the eyes of the region, sorely undermining its foundational independence,  and enfeebling himself politically a few months before elections. Or he could defy the US president and embark on what would almost certainly turn into an escalating war with Iran in which Israel could find itself quite alone. 

 But as Israel prepared to “respond forcefully” against Iran, in the words of an unnamed senior Israeli official, US President Donald Trump ordered it to think again.

Before he had even spoken to Prime Minister Benjamin Netanyahu, his partner of 100 days ago, the president was telling his favorite Israeli journalist, Barak Ravid, that Israel had better not hit back: “I am going to call Bibi right now and tell him not to retaliate,” Trump vouchsafed. “Each of them had their fun. Israel had its strike and Iran had its strike. We don’t need another one.”

Trump has repeatedly denied claims that Netanyahu dragged him and the United States into the war. But he has made it increasingly clear that he is desperate to end the inadequately planned campaign, even with none of the declared US-Israeli goals achieved. He’s still insisting that he is holding out for terms that will ensure the regime never gets nuclear weapons, but there’s no guarantee of that in the leaked drafts of the memorandum of understanding he’s been working toward. And his overriding priority is to get the Strait of Hormuz reliably open again and alleviate the global energy chaos that Tehran has proved so adept at creating.

Even as Iran was firing on the north, Trump was asserting for the umpteenth time that he is days away from a deal with the manifestly obdurate and duplicitous regime: “I would say an agreement would be signed on Monday, Tuesday or Wednesday of this coming week,” the US president claimed. “And now this takes place,” he groused.

Trump’s “don’t retaliate” demand left Netanyahu with a stark choice. He could indeed surrender to the presidential diktat and hold his fire, destroying more of Israel’s deterrent capability against a gloating, triumphant Tehran, rendering Israel weak in the eyes of the region, sorely undermining its foundational independence,  and enfeebling himself politically a few months before elections. Or he could defy the US president and embark on what would almost certainly turn into an escalating war with Iran in which Israel could find itself quite alone.

More than 35 years ago, under Netanyahu’s generally intransigent Likud prime ministerial predecessor Yitzhak Shamir, Israel agreed to hold fire when it came under missile attack — Scud missile attack by Iraq’s Saddam Hussein. But that was to avoid fracturing president George H. Bush’s US-led coalition, including many Middle Eastern nations, bent on taking down a tyrannical aggressor, not accommodating one.

First reports on the Sunday night call, again from Ravid, suggested that Netanyahu tried in vain to overcome Trump’s opposition to an Israeli counterstrike, and that the US believed Netanyahu would not order a retaliatory attack in the near future. First reports, it turned out soon afterward, did not tell the full story.

Michael Oren, the former Israeli ambassador to the United States, speculated that Netanyahu might also have sought Trump’s support for an “under-the-radar” attack on Iran for which Israel would not claim credit or, alternatively, some kind of tangible benefit for its restraint, perhaps in the shape of America’s B-2 stealth bombers, uniquely capable of pounding Iran’s underground nuclear facilities in a future hour of need. The prime minister might also have sought to try, once again, to talk Trump out of the kind of lousy deal he is working toward, under which Iran can reliably expect to stave off any substantive compromise on its nuclear weapons drive.

But all of that seemed unlikely. Netanyahu was facing a president who has not disputed calling him “fucking crazy” last week and telling him that everybody hates him and hates Israel. A president whose domestic political needs require anything but an escalation. A president in a pretty bad mood

A key question now is whether the regime is feeling so bullish, so emboldened, as to overplay its hand even against a US president so blatantly desirous of a settlement. Could Iran, that is, so frustrate Trump as to compel him, against his will, to do what he ordered Netanyahu not to do, and revive the military campaign?

On past and current performance, the Islamic Republic is too canny to make that mistake. Which leaves a frustrated American president playing the supplicant to a duplicitous Iran, with Israel in the middle. 

In another of his Sunday interviews, with the Financial Times, Trump said that if he couldn’t reach a deal with Tehran, he might either “go in and take care of the rest of the place that we didn’t take care of militarily,” or maintain the current blockade.

But he was certain about one thing: Netanyahu would have to accept any deal he agreed with the regime. “He won’t have any choice,” Trump said of Netanyahu. “I call the shots. I call all the shots.”

Not in Iran, he doesn’t.

Dr Ruth Report, 6-7-26

Here's Dr Ruth Ann Crystal's latest report containing lots of information on very important medical topics!

-------------------------------------------------- 

Dr. Ruth Report, 6/7/26

Hi all,

Before you scroll past, please check out the Government News and Other News sections at the end of this issue of the newsletter. There is a Friday night executive order you may have missed, diabetes researchers removed by police at the ADA medical conference, a personalized melanoma vaccine with striking five-year results, and an Alzheimer’s case report that is surprising.

Weekly Virus Summary

COVID, RSV, Influenza A, and Influenza B remain low in wastewater across the country. In fact, COVID wastewater levels are their lowest in 5 years.

From: WastewaterSCAN

COVID

COVID data through 5/23/26 from Mike Hoerger:

  • 1 in 277 Americans are currently infected with COVID which equals to about 177,000 new daily COVID infections in the U.S., and 1.2 Million new COVID infections per week.

  • SARS-CoV-2 transmission remains at its lowest levels nationwide since mid-July 2021.

6/3/26 Newsweek: Worrying COVID ‘cicada’ variant spreads as US maps go dark https://buff.ly/Dq65XAn

  • Newly proposed federal budget cuts would slash CDC wastewater surveillance funding from $125 million to $25 million annually, threatening the national early warning system experts say detects outbreaks weeks before clinical cases emerge.

Acute COVID infections, General COVID info

6/4/26 MedRxiV: Shared epigenetic regulation acting on neuroimmune pathways contributes to the comorbidity between generalized anxiety disorder and COVID-19

  • Yale researchers analyzed genes from 893 participants and found that “generalized anxiety disorder (GAD) and COVID-19 share epigenetic and genetic architecture involving pathways related to vascular integrity, immune function, and cellular adaptation, highlighting a potential neuroimmune basis for their co-occurrence.” They found 60 overlapping genetic loci between GAD and COVID and brain-specific analyses flagged HLA and MICB genes.

6/2/26 Nature Sci Reports: A 19-layer convolutional neural network for accurate COVID-19 detection in chest X-ray images: comparative analysis with pretrained networks

  • Using a new 19-layer convolutional neural network to evaluate 25,679 chest X-rays, Singaporean researchers found that the model was 98.4% and 97.5% accurate for diagnosing COVID infection. The model outperformed several established pretrained networks in image classification performance, but whether this translates to measurable improvements in real world patient outcomes would require clinical trials.

Pediatrics

6/3/26 Nature Scientific Reports: Retinal microvascular alterations consistent with endothelial dysregulation in paediatric post-COVID-19 syndrome: A prospective matched-cohort study

  • German scientists examined the eyes of 74 pediatric patients with Long COVID and found measurable retinal microvascular abnormalities. These vascular changes, detectable through noninvasive eye imaging, point to disrupted endothelial cell function and abnormal blood flow patterns and may reflect microvascular issues in other organs in children with Long COVID.

Made with ChatGPT

Share

6/3/26 BioRxiV: SARS-CoV-2 BA.3.2.2 is more evasive of neutralization by sera from young children

  • BA.3.2 is a fairly new COVID variant that appears to infect children more than adults. Columbia University researchers found that young children produced substantially weaker neutralizing antibody responses to the BA.3.2.2 variant compared to adults, while antibody responses to the XFG and NB.1.8.1 variants were broadly comparable across all age groups. Prior infection and vaccination histories, which differ considerably between children and adults, may be driving differences in immune protection against specific emerging variants.

Antiviral treatments

6/1/26 Shionogi Announces FDA Approval of XOCOVA® (ensitrelvir), the First and Only Oral Option to Help Prevent COVID-19 Following Exposure

  • The FDA approved Ensitrelvir (XOCOVA) this week, making it the first oral medication indicated for preventing COVID following known exposure to the virus. In a Phase 3 clinical trial, the drug reduced the incidence of symptomatic COVID-19 by 67%, functioning by suppressing viral replication before symptoms have a chance to develop.

Made with ChatGPT

Share

Long COVID

Comment here by June 11:

https://www.federalregister.gov/documents/2026/05/12/2026-09366/drug-repurposing-for-unmet-medical-needs-request-for-information

PolyBio posted summaries of presentations and links to the talks from their recent PolyBio Spring 2026 Symposium

https://2026-spring-symposium-polybio.netlify.app/

  • “Twenty-eight research presentations on Long COVID, ME/CFS, and related infection-associated chronic illness. Each card opens to a full technical summary.”

  • PolyBio topics discussed:

6/2/26 Applied Psychopharmacology: The expanding potential of low-dose naltrexone in clinical practice with a focus on long COVID

  • Researchers at the VA Northeast Ohio Healthcare System conducted a review of existing small-scale studies examining low-dose naltrexone (LDN) as a potential treatment for Long COVID. The findings suggested an association between LDN and reductions in fatigue, post-exertional malaise, disrupted sleep, and cognitive impairment, with researchers pointing to the suppression of neuroinflammation as a likely underlying mechanism. Evidence remains preliminary, however.

    Share

5/31/26 Journal of Sleep Research: Association of Prodromal Parkinson’s Disease-Like Features in Long COVID With Dream-Enactment Behaviours

  • Dream enactment behaviors (DEBs) are when someone physically acts out their dreams with movements or vocalizations during sleep. A large multinational study found that Long COVID patients show significantly elevated rates of prodromal Parkinson’s disease features including loss of smell, constipation, excessive daytime sleepiness, and cognitive difficulties. People with Long COVID who also developed or worsened DEBs had the highest risk. Because frequent DEBs can be an early marker of neurodegeneration including Parkinson’s and Lewy body dementia, the authors call for long term neurological monitoring of Long COVID patients.

Figure 2: Forest plot of adjusted odds ratios for potential prodromal PD-like features in participants with Long COVID (weighted sample).

From: https://onlinelibrary.wiley.com/doi/10.1111/jsr.70371

6/4/26 BioRxiV (UCSF): No objective evidence of neuropsychological deficits in people with subjective cognitive changes following COVID-19 infection

  • UCSF scientists studied 86 people and found that individuals who reported brain fog following COVID infection did not have measurable cognitive deficits on standardized tests, yet they demonstrated elevated levels of the inflammation marker sCD14 along with greater rates of anxiety, depression, and the APOE ε4 genetic variant. These findings suggest that the subjective experience of post COVID cognitive impairment may reflect underlying neuroinflammatory and psychological processes that standard cognitive assessments are not designed to detect.

5/29/26 BMC Public Health: Bidirectional relationship between depression and long COVID symptoms: findings from the Sulcovid-19 longitudinal survey

  • Researchers studying 2,919 Brazilian adults with prior COVID infection found that depression and Long COVID symptoms mutually amplify one another, creating a reinforcing cycle. A history of depression increased the likelihood of neurological Long COVID symptoms, and experiencing Long COVID raised the odds of a subsequent depression diagnosis by 65%.

5/30/26 Respiratory Medicine: Inspiratory Muscle Fatigue and Pulmonary Deposition–Perfusion Imaging Predict Sleep Dysfunction in Long COVID: Evidence From MTC Scintigraphy and FIT Performance Metrics

  • Brazilian scientists studied 33 Long COVID patients and found that weakened inspiratory muscles corresponded with reduced aerosol deposition and abnormal perfusion patterns on scintigraphy, alongside disrupted sleep. Inspiratory muscle fatigue was a strong predictor of impaired lung ventilation, pointing to a mechanistic link between breathing muscle dysfunction and broader respiratory and sleep impairments in Long COVID.

Figure 4 Representative ventilation and perfusion scintigraphy images comparing symptomatic and asymptomatic post-COVID-19 individuals.

From: https://www.resmedjournal.com/article/S0954-6111(26)00288-X/fulltext

Here is a helpful explainer video from Tokyo on the basics of Long COVID:

6/3/26 Infectious Diseases and Therapy: Prior SGLT2 Inhibitor and Metformin Use and Risk of Long COVID in Type 2 Diabetes: A Nationwide Population-Based Cohort Study

  • Researchers from Singapore analyzed 71,698 adults with Type 2 Diabetes and found that those who had previously taken SGLT2 inhibitors or metformin faced a meaningfully lower risk of developing Long COVID, with SGLT2 inhibitors showing a particularly notable association with reduced neurological complications. As this was an observational cohort study, it cannot establish that either medication directly protects against Long COVID, so more studies are needed.

6/4/26 Military Medicine: Lung Function in Young, Active Duty U.S. Marines After SARS-CoV-2 Infection

  • The Naval Medical Research Command evaluated lung function in 889 Marines (mean age 19 years). Among those infected with COVID-19, nearly 25% reported Long COVID (PASC). Marines with PASC had reduced peak expiratory flow compared with recovered peers, suggesting subtle airway dysfunction that standard spirometry may miss, even in young, physically fit adults.

6/1/26 Wired by Alan Levinovitz: The Painful Truth About Long Covid https://buff.ly/bAYh0iE

  • This week, Alan Levinovitz wrote an article in Wired magazine that received sharp criticism from the Long COVID community. He wrote about people recovering from Long COVID by doing “brain retraining”, but patients and researchers pointed out on Twitter and Instagram that the article was biased with cherry picked data that did not represent the experiences of most Long COVID patients.

MCAS

6/4/26 Diagnosis Journal: Progress in mast cell activation syndrome: the global consensus-2 diagnostic criteria at six years https://buff.ly/5DcTlYg

  • Six years after consensus-2 diagnostic criteria were introduced for Mast Cell Activation Syndrome (MCAS), fears of overdiagnosis have not materialized, according to a new review. Appropriate treatment can dramatically improve quality of life for patients who often spent decades undiagnosed. MCAS frequently co-occurs with dysautonomia and EDS, with POTS as its most common comorbidity.

Measles

CDC Measles update (Wednesdays):

  • As of June 4, 2026, 2,030 confirmed measles cases were reported in the United States in 2026 so far.

  • South Carolina’s measles outbreak is over after 997 cases.

John Hopkins US Measles Tracker

In the past 2 weeks:

  • Central Virginia has had 17 measles cases in the last 2 weeks.

  • Utah has had 34 measles cases in the last 2 weeks.

New World Screwworm

6/4/26 CIDRAP: Texas reports New World screwworm in 3-week-old calf

  • Texas reports New World screwworm in a 3-week-old calf. This is the first detection of larva of the parasitic fly in the U.S. in 60 years. The screwworm poses a significant threat to livestock and pets, but it rarely infects humans.

Ebola

6/1/26 NBC: As Ebola spreads, the institute Fauci once led (NIAID) stays on the sidelines without a leader https://buff.ly/QXMdlbQ

6/5/26 CIDRAP: WHO, Africa CDC announce joint Ebola response plan https://buff.ly/bfHwd4o

June 4 update from the government of DRC:

Government Health News

6/1/26 Melanie Matheu PhD (Lil Science): The President’s Friday Night Executive Order He Didn’t Want You To See: Elimination of Recommendations for 6 Childhood Vaccines

  • On May 29, 2026, President Trump signed an executive order removing six childhood vaccines from the CDC recommended schedule, including Influenza, COVID-19, Rotavirus, Hepatitis A, Hepatitis B birth dose, and Meningococcal vaccines. A court previously blocked the RFK Jr. appointed ACIP committee from making these same changes. Many states are now following the guidance of the American Academy of Pediatrics (AAP) instead of the CDC.

6/1/26 NY Times: Trump Administration Announces Stricter Rules for Medicaid Work Requirement

  • “A new rule by the Trump administration could make it even harder for millions of sick Americans to obtain or stay on Medicaid after work requirements start next year.” Adults on Medicaid will be required to work 80 hours per month. It is hard to work when you are sick with cancer or HIV.

6/2/26 NY Times: New Proposal Would Allow Administration to Block Grants if They Don’t Support Trump’s Agenda

  • “A new proposal would allow the administration to block grants if they do not satisfy President Trump’s agenda or support what it calls “anti-American” values... The proposal was only the latest attempt by the Office of Management and Budget, led by Russell T. Vought, to exert power over federal funding.”

6/5/26 MedPage Today: Video: Police Tussle With Diabetes Experts at ADA Meeting

  • At the American Diabetes Association‘s annual meeting in New Orleans, police escorted out senior researchers, including the Editor in Chief of the ADA’s journal Diabetes Care, for distributing copies of an editorial the journal had published criticizing Trump administration cuts to biomedical research. The editorial warned that NIH funding reductions threaten diabetes research and outcomes.

Here is the article that the doctors were passing out to their colleagues:

  • 4/29/26 Diabetes Care:

Misguided Brushes of a Pen Continue to Dismantle and Destroy Biomedical Research in the United States: We Can No Longer Afford Complacency and Fear. We Must All Act Now!

From: Medpage Today

Share

6/4/26 Wash Po: House bill rolls back food aid for pregnant women, children

  • “Millions of WIC recipients would have less money for fruits and vegetables under the legislation.”

6/2/26 Nature Medicine: Medically tailored meals receipt and healthcare utilization and costs in Massachusetts’ Medicaid demonstration

  • A new study shows that if you give people healthy meals, they have fewer hospitalizations, fewer emergency department visits, and lower healthcare costs. Ironically, the House voted to remove funding for pregnant women and children to have fresh fruits and vegetables this week.

6/5/26 NPR: South Africa rolls out game-changing HIV shot amid funding shortfalls

  • Lenacapavir is a new medication that can be given by injection once every 6 months to prevent HIV infections. South Africa is rolling out a program to provide Lenacapavir to reduce HIV infection rates, but cuts to USAID mean that access will be limited.

Other news

6/6/26 Journal of the American Heart Association: Glucagon‐Like Peptide‐1 Receptor Agonists and Cardiovascular Events in Adults With Obesity and Autoimmune Disease: A Target Trial Emulation

  • In a propensity-matched analysis of more than 26,000 adults with both obesity and autoimmune disease, GLP-1 receptor agonists were linked to reduced mortality, stroke, pulmonary embolism, and emergency room visits.

5/27/26 Frontiers in Neuroscience: Transient multidomain functional improvement in advanced Alzheimer’s disease following high-dose psilocybin-containing mushroom administration: a case report

  • A woman in her 80s with advanced Alzheimer’s disease could barely speak, had a flat affect, was incontinent, and could not walk. After taking a high dose of psilocybin mushrooms, she initially went into a sleep-like state and then woke up 19 hours later able to speak in full sentences, sharing detailed memories. Over the next few days, her family reported improved memory, ability to walk, emotional connection, and regained bladder control. This is a single case report, but the results are promising.

Made with ChatGPT

6/1/26 Journal of Clinical Oncology: Intismeran Autogene Plus Pembrolizumab Versus Pembrolizumab Alone in High-Risk Resected Melanoma: 5-Year Update of the Randomized Phase 2b KEYNOTE-942 Study

  • Wow! Five-year follow-up of a randomized trial finds that adding a personalized mRNA neoantigen vaccine called Intismeran autogene to Keytruda (pembrolizumab) cut metastatic melanoma recurrence and death by 49% compared to Keytruda alone. At five years, 69% of vaccine recipients were cancer-free versus 49% in the Keytruda-only group, with overall survival of 92% versus 71%. Distant metastasis of melanoma was also reduced by 59% with the addition of the personalized vaccine.

Figure 1. Kaplan-Meier estimates of Relapse-Free Survival (RFS). RFS was defined as time from first pembrolizumab dose to first recurrence (local, regional, or distant metastasis) by investigator assessment, new primary melanoma, or death from any cause.

From: https://ascopubs.org/doi/10.1200/JCO-26-00835

Share

6/4/26 Cell: Plasma signals of lung tumor promotion for molecular cancer prevention

  • Researchers identified a 14-protein plasma signature that predicts lung cancer more than five years before diagnosis, validated across eight cohorts. The signature, discovered using machine learning, also identifies patients likely to benefit from anti-IL-1β preventive therapy, pointing toward a molecular early warning system for the disease.

Yesterday was D-Day, when the allied forces invaded Normandy. Historian Dr. Helen Fry shared the story of Gustav the carrier pigeon who flew 150 miles to Britain to relay news of D-Day success.

6/4/26 Space.com: Meteorite found in Sahara desert may be 1st evidence of lost solar system world

  • A one pound meteorite found in the Sahara desert in 2019 may be the first physical evidence of a lost planet. Researchers at the University of Colorado Boulder identified it as an angrite, one of the oldest volcanic rock types in the solar system, with a chemical makeup distinct from Earth and Mars. Mineral crystals inside formed under pressures requiring a parent body at least the size of Earth’s moon, suggesting the rock originated from a now-destroyed protoplanet that existed 4.5 billion years ago.

John Kashuba, CU Boulder

6/21/26 NY Times: ‘La La Land’ Orchestral Performance Saved by Keyboardist in the Audience

  • When the keyboardist fell ill mid-performance at a Sydney orchestral showing of La La Land, composer Justin Hurwitz asked the 2,000-person audience for a sight reader. 21-year-old University of Sydney student Sterling Nasa stepped up, delivered a solo on “Start a Fire,” and walked away considering music as his new career.

Photo: Lindsay Harapa, via Storyful

Have a good week,

Ruth Ann Crystal MD

Sunday, June 07, 2026

NOW Can We stop Talking About "Peace" With Iran?!

No more Blinkenitis. Israel should be unleashed to respond and to attack Iran -- and so should we. This long so-called ceasefire waiting for a "peace deal" that will never happen has achieved nothing except to embolden Iran even more. We have to destroy them, period.

Look at the map and see how large Iran is compared to Israel. Israel is right to protect herself and retaliate against Hezbolleh, Hamas, and Iran.  That's the only response our enemies understand!

----------------------------------------- 

Times of Israel, 6-7-26

Sirens sound across northern Israel amid Iranian ballistic missile attack

Two Iranian ballistic missiles shot down, in first attack since April 8 ceasefire 

Saturday, June 06, 2026

D-Day, June 6, 1944: The Greatest Generation of Men, Heroes, and Leaders

 

The clip above shows 107 war veteran Arthur Rose reading a letter he had sent to his parents. 

The Allied liberation of Europe beginning with the invasion of Normany, France, went off spectacularly well, considering it involved 160,000 troops and several countries, and no cell phones or internet to make it easier. The coordination among men and countries was brilliant in its planning, and we were lucky to have Eisenhower as the commander. 

Here's another commemoration, on the British side:

D-Day veterans gather for 82nd anniversary of Normandy landings amid poignant commemorations by French schoolchildren and the grandson of Field Marshal Montgomery 

"Veterans have gathered for the 82nd Anniversary of the Normandy landings as French children and the grandson of Field Marshal Montgomery take part in poignant commemorations.

"Today in 1944, on a cool, cloudy June morning, nearly 160,000 Allied troops landed on beaches across Normandy to carry out the largest seaborne invasion in history.

"Their brave actions began the liberation of Nazi-occupied France and turned the tide of the Second World War that would eventually lead to the defeat of Hitler's forces in 1945."

Friday, June 05, 2026

Hilarious! The Babylon Bee on California Vote-Counting

Here's The Babylon Bee's hilarious take on California's ridiculously slow counting of ballots:

California Announces They Have Finished Counting The Votes, Ronald Reagan Has Won The 1966 Governor's Race

Politics · Jun 3, 2026 · BabylonBee.com
Image for article: California Announces They Have Finished Counting The Votes, Ronald Reagan Has Won The 1966 Governor's Race

"SACRAMENTO, CA — California officials announced on Wednesday that they had finally finished counting the votes and Ronald Reagan had officially won the 1966 governor's race.

"Exit polling data showed Reagan with an early lead on the night of November 8, 1966, but election officials were hesitant to declare a winner before each and every vote was painstakingly tabulated. Now, 59 years later, Reagan was declared California's next governor.

"I'm excited to see how Reagan will clean up our state," said one voter. "He didn't say much about the fentanyl crisis back in 1966, but I'm confident he'll work hard to get it off our streets."

"Is this the beginning of California becoming a red state? It's too soon to tell, say experts. "What concerned voters in 1966 doesn't necessarily concern them today," said Dr. Abel Hemming, a political strategist and historian. "Reagan doesn't even have a plan to prevent wildfires because they weren't a big problem back then. So I'm not sure how well he's going to go over with today's Californians."

"Reagan, a former screen actor, could not be reached for comment.

"At publishing time, it was revealed that Ronald Reagan, who apparently served two consecutive terms as President of the United States in the 1980s, had sadly passed away in 2004 and therefore could not serve his gubernatorial term."